The Putative PAX8/PPARγ Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPARγ Activity

In vitro studies have demonstrated that the PAX8/PPARγ fusion protein (PPFP), which occurs frequently in follicular thyroid carcinomas (FTC), exhibits oncogenic activity. However, paradoxically, a meta-analysis of extant tumor outcome studies indicates that 68% of FTC-expressing PPFP are minimally i...

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Detalhes bibliográficos
Main Authors: Reddi, Honey V., Madde, Pranathi, Milosevic, Dragana, Hackbarth, Jennifer S., Algeciras-Schimnich, Alicia, McIver, Bryan, Grebe, Stefan K.G., Eberhardt, Norman L.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111009/
https://ncbi.nlm.nih.gov/pubmed/21779480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601911405045
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