Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts

BACKGROUND: We investigated whether p42/p44 extracellular signal-regulated kinases (ERK1/2) and/or phosphatidylinositol-3-OH kinase (PI3K)-Akt play a crucial role in cardioprotection by κ-opioid receptor (KOP) activation. METHODS: Langendorff perfused rat hearts were subjected to 30 min of regional...

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Bibliografiske detaljer
Main Authors: Kim, June Hong, Jang, Young Ho, Chun, Kook Jin, Kim, Jun, Park, Yong Hyun, Kim, Jeong Su, Kim, Jin Mo, Lee, Mi Young
Format: Artigo
Sprog:Inglês
Udgivet: The Korean Society of Anesthesiologists 2011
Fag:
Experimental Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110294/
https://ncbi.nlm.nih.gov/pubmed/21716908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4097/kjae.2011.60.5.351
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