Enhanced Immunogenicity, Mortality Protection, and Reduced Viral Brain Invasion by Alum Adjuvant with an H5N1 Split-Virion Vaccine in the Ferret

BACKGROUND: Pre-pandemic development of an inactivated, split-virion avian influenza vaccine is challenged by the lack of pre-existing immunity and the reduced immunogenicity of some H5 hemagglutinins compared to that of seasonal influenza vaccines. Identification of an acceptable effective adjuvant...

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Main Authors: Layton, Robert Colby, Gigliotti, Andrew, Armijo, Penny, Myers, Leslie, Knight, Jennifer, Donart, Nathaniel, Pyles, John, Vaughan, Sarah, Plourde, Jennifer, Fomukong, Ndingsa, Harrod, Kevin S., Gao, Peng, Koster, Frederick
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3110201/
https://ncbi.nlm.nih.gov/pubmed/21687736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020641
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