Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes

INTRODUCTION: Myelodysplastic syndromes encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis, refractory cytopenia and a tendency to progress toward acute myeloid leukemia. The accumulation of genetic alterations is closely associated...

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Bibliographische Detailangaben
Hauptverfasser: Machado-Neto, João Agostinho, Traina, Fabiola, Lazarini, Mariana, de Melo Campos, Paula, Pagnano, Katia Borgia Barbosa, Lorand-Metze, Irene, Costa, Fernando Ferreira, Olalla Saad, Sara T
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2011
Schlagworte:
Clinical Science
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109377/
https://ncbi.nlm.nih.gov/pubmed/21789382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1807-59322011000500014
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