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Structure of C3PO and Mechanism of Human RISC Activation
Assembly of the RNA-induced silencing complex (RISC) consists of loading duplex (guide/passenger) siRNA onto and removing the passenger strand from Argonaute (Ago2). Ago2 contributes critically to RISC activation by nicking the passenger strand. Here, we reconstituted duplex siRNA-initiated RISC act...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109212/ https://ncbi.nlm.nih.gov/pubmed/21552258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2032 |
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