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Mitochondrial DNA Damage and Repair in RPE Associated with Aging and Age-Related Macular Degeneration

PURPOSE. Mitochondrial DNA (mtDNA) damage may be associated with age-related diseases, such as age-related macular degeneration (AMD). The present study was designed to test whether the frequency of mtDNA damage, heteroplasmic mtDNA mutations, and repair capacity correlate with progression of AMD. M...

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Main Authors: Lin, Haijiang, Xu, Haifeng, Liang, Fong-Qi, Liang, Hao, Gupta, Praveena, Havey, Anna N., Boulton, Michael E., Godley, Bernard F.
Formato: Artigo
Idioma:Inglês
Publicado: Association for Research in Vision and Ophthalmology, Inc. 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109040/
https://ncbi.nlm.nih.gov/pubmed/21273542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6163
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