Retinoic Acid-Treated Pluripotent Stem Cells Undergoing Neurogenesis Present Increased Aneuploidy and Micronuclei Formation

The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate into the mature...

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Bibliographic Details
Main Authors: Sartore, Rafaela C., Campos, Priscila B., Trujillo, Cleber A., Ramalho, Bia L., Negraes, Priscilla D., Paulsen, Bruna S., Meletti, Tamara, Costa, Elaine S., Chicaybam, Leonardo, Bonamino, Martin H., Ulrich, Henning, Rehen, Stevens K.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108948/
https://ncbi.nlm.nih.gov/pubmed/21674001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020667
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