Differential DNA damage responses in p53 proficient and deficient cells: cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53-deficient lung cancer cells

Nucleotide excision repair (NER) and ataxia telangiectasia mutated (ATM)/ATR (ATM- and RAD3-related) DNA damage checkpoints are among the major pathways that affect the chemotherapeutic efficiency of the anticancer drug cisplatin. Xeroderma pigmentosum group A (XPA) protein plays a crucial role in N...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Li, Zhengke, Musich, Phillip R., Zou, Yue
Materialtyp: Artigo
Språk:Inglês
Publicerad: e-Century Publishing Corporation 2011
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107498/
https://ncbi.nlm.nih.gov/pubmed/21643554
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