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High sensitivity to aligner and high rate of false positives in the estimates of positive selection in the 12 Drosophila genomes
We investigate the effect of aligner choice on inferences of positive selection using site-specific models of molecular evolution. We find that independently of the choice of aligner, the rate of false positives is unacceptably high. Our study is a whole-genome analysis of all protein-coding genes i...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3106319/ https://ncbi.nlm.nih.gov/pubmed/21393387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.115949.110 |
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