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Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide–gated channels
Cyclic nucleotide–gated (CNG) channels bind cGMP or cAMP in a cytoplasmic ligand–binding domain (BD), and this binding typically increases channel open probability (P(o)) without inducing desensitization. However, the catfish CNGA2 (fCNGA2) subtype exhibits bimodal agonism, whereby steady-state P(o)...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3105518/ https://ncbi.nlm.nih.gov/pubmed/21624949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201010560 |
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