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2D-LC Analysis of BRP 3 Erythropoietin N-Glycosylation using Anion Exchange Fractionation and Hydrophilic Interaction UPLC Reveals Long Poly-N-Acetyl Lactosamine Extensions

Post translational modifications, in particular glycosylation, represent critical structural attributes that govern both the pharmacodynamic and pharmacokinetic properties of therapeutic glycoproteins. To guarantee safety and efficacy of recombinant therapeutics, characterization of glycosylation pr...

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Bibliografske podrobnosti
Main Authors: Bones, Jonathan, McLoughlin, Niaobh, Hilliard, Mark, Wynne, Kieran, Karger, Barry L., Rudd, Pauline M.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105185/
https://ncbi.nlm.nih.gov/pubmed/21504189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac200406z
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