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Crystal Structure and Allosteric Activation of Protein Kinase C βII
Protein kinase C (PKC) isozymes are the paradigmatic effectors of lipid signaling. PKCs translocate to cell membranes and are allosterically activated upon binding of the lipid diacylglycerol to their C1A and C1B domains. The crystal structure of full-length protein kinase C βII was determined at 4....
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104240/ https://ncbi.nlm.nih.gov/pubmed/21215369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.12.013 |
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