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Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

Epidermal growth factor receptor (EGFR) is overexpressed in many cancer types including ∼30% of breast cancers. Several small molecule tyrosine kinase inhibitors (TKIs) targeting EGFR have shown clinical efficacy in lung and colon cancers, but no benefit has been noted in breast cancer. Thirteen EGF...

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Autori principali: Irwin, Mary E., Mueller, Kelly L., Bohin, Natacha, Ge, Yubin, Boerner, Julie L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103760/
https://ncbi.nlm.nih.gov/pubmed/21660955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22570
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