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Imatinib has deleterious effects on differentiating spermatogonia while sparing spermatogonial stem cell self renewal

Imatinib mesylate is among a growing number of effective cancer drugs that provide molecularly targeted therapy; however, imatinib causes reproductive defects in rodents. The availability of an in vitro system for screening the effect of drugs on spermatogenesis would be beneficial. The imatinib tar...

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Autori principali: Heim, Crystal, Minniear, Kayla, Dann, Christina Tenenhaus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103660/
https://ncbi.nlm.nih.gov/pubmed/21295132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2010.12.056
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