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Imatinib has deleterious effects on differentiating spermatogonia while sparing spermatogonial stem cell self renewal
Imatinib mesylate is among a growing number of effective cancer drugs that provide molecularly targeted therapy; however, imatinib causes reproductive defects in rodents. The availability of an in vitro system for screening the effect of drugs on spermatogenesis would be beneficial. The imatinib tar...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103660/ https://ncbi.nlm.nih.gov/pubmed/21295132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2010.12.056 |
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