Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes

RAS activation is implicated in physiologic and pathologic cardiac hypertrophy. Cross-talk between the Ras and calcineurin pathways, the latter also having been implicated in cardiac hypertrophy, has been suspected for pathologic hypertrophy. Our recent discovery that germ-line mutations in RAF1, wh...

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Hauptverfasser: Dhandapany, Perundurai S, Fabris, Frank, Tonk, Rahul, Illaste, Ardo, Karakikes, Ioannis, Sorourian, Mehran, Sheng, Jipo, Hajjar, Roger J., Tartaglia, Marco, Sobie, Eric A., Lebeche, Djamel, Gelb, Bruce D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103595/
https://ncbi.nlm.nih.gov/pubmed/21440552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.03.001
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