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Lysophosphatidate Induces Chemo-Resistance by Releasing Breast Cancer Cells from Taxol-Induced Mitotic Arrest

BACKGROUND: Taxol is a microtubule stabilizing agent that arrests cells in mitosis leading to cell death. Taxol is widely used to treat breast cancer, but resistance occurs in 25–69% of patients and it is vital to understand how Taxol resistance develops to improve chemotherapy. The effects of chemo...

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Autors principals: Samadi, Nasser, Bekele, Raie T., Goping, Ing Swie, Schang, Luis M., Brindley, David N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103588/
https://ncbi.nlm.nih.gov/pubmed/21647386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020608
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