SARS-CoV 9b Protein Diffuses into Nucleus, Undergoes Active Crm1 Mediated Nucleocytoplasmic Export and Triggers Apoptosis When Retained in the Nucleus

BACKGROUND: 9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning...

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Main Authors: Sharma, Kulbhushan, Åkerström, Sara, Sharma, Anuj Kumar, Chow, Vincent T. K., Teow, Shumein, Abrenica, Bernard, Booth, Stephanie A., Booth, Timothy F., Mirazimi, Ali, Lal, Sunil K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103500/
https://ncbi.nlm.nih.gov/pubmed/21637748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019436
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