The Interferon-γ-induced GTPase, mGBP-2, Inhibits Tumor Necrosis Factor α (TNF-α) Induction of Matrix Metalloproteinase-9 (MMP-9) by Inhibiting NF-κB and Rac Protein

Matrix metalloproteinase-9 (MMP-9) is important in numerous normal and pathological processes, including the angiogenic switch during tumor development and tumor metastasis. Whereas TNF-α and other cytokines up-regulate MMP-9 expression, interferons (IFNs) inhibit MMP-9 expression. We found that IFN...

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Autors principals: Balasubramanian, Sujata, Fan, Meiyun, Messmer-Blust, Angela F., Yang, Chuan H., Trendel, Jill A., Jeyaratnam, Jonathan A., Pfeffer, Lawrence M., Vestal, Deborah J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103378/
https://ncbi.nlm.nih.gov/pubmed/21502320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.249326
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