A Disease-associated Polymorphism Alters Splicing of the Human CD45 Phosphatase Gene by Disrupting Combinatorial Repression by Heterogeneous Nuclear Ribonucleoproteins (hnRNPs)

Alternative splicing is typically controlled by complexes of regulatory proteins that bind to sequences within or flanking variable exons. The identification of regulatory sequence motifs and the characterization of sequence motifs bound by splicing regulatory proteins have been essential to predict...

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Main Authors: Motta-Mena, Laura B., Smith, Sarah A., Mallory, Michael J., Jackson, Jason, Wang, Jiarong, Lynch, Kristen W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103377/
https://ncbi.nlm.nih.gov/pubmed/21507955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218727
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