Ca(2+)-dependent Monomer and Dimer Formation Switches CAPRI Protein between Ras GTPase-activating Protein (GAP) and RapGAP Activities

CAPRI is a member of the GAP1 family of GTPase-activating proteins (GAPs) for small G proteins. It is known to function as an amplitude sensor for intracellular Ca(2+) levels stimulated by extracellular signals and has a catalytic domain with dual RasGAP and RapGAP activities. Here, we have investig...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Dai, Yanfeng, Walker, Simon A., de Vet, Edwin, Cook, Simon, Welch, Heidi C. E., Lockyer, Peter J.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2011
الموضوعات:
Signal Transduction
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103366/
https://ncbi.nlm.nih.gov/pubmed/21460216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.201301
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