Fibroblast Growth Factor Receptor 3 (FGFR3) Is a Strong Heat Shock Protein 90 (Hsp90) Client: IMPLICATIONS FOR THERAPEUTIC MANIPULATION

Fibroblast growth factor receptor 3 (FGFR3) is a key regulator of growth and differentiation, whose aberrant activation causes a number of genetic diseases including achondroplasia and cancer. Hsp90 is a specialized molecular chaperone involved in stabilizing a select set of proteins termed clients....

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Bibliographic Details
Main Authors: Laederich, Melanie B., Degnin, Catherine R., Lunstrum, Gregory P., Holden, Paul, Horton, William A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103339/
https://ncbi.nlm.nih.gov/pubmed/21487019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.206151
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