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The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.
Some transcription factors contain stretches of polyglutamine encoded by repeats of the trinucleotide CAG. Expansion of the CAG repeat in the androgen receptor (AR) has been correlated with the incidence and severity of X-linked spinal and bulbar muscular atrophy (Kennedy's disease). In order t...
Gardado en:
| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
1994
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| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310294/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8065934/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.15.3181 |
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