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Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
DNA methyltransferase 1 (DNMT1) is crucial for maintenance of methylation, gene regulation and chromatin stability(1-3). DNA mismatch repair, cell cycle regulation in post-mitotic neurons(4,5) and neurogenesis(6) are influenced by DNA methylation. Here we show mutations in DNMT1 cause both central a...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102765/ https://ncbi.nlm.nih.gov/pubmed/21532572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.830 |
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