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Suboptimal Activation of Antigen-Specific CD4(+) Effector Cells Enables Persistence of M. tuberculosis In Vivo

Adaptive immunity to Mycobacterium tuberculosis controls progressive bacterial growth and disease but does not eradicate infection. Among CD4(+) T cells in the lungs of M. tuberculosis-infected mice, we observed that few produced IFN-γ without ex vivo restimulation. Therefore, we hypothesized that o...

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Bibliografiske detaljer
Main Authors: Bold, Tyler D., Banaei, Niaz, Wolf, Andrea J., Ernst, Joel D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102708/
https://ncbi.nlm.nih.gov/pubmed/21637811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002063
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