Selective Toxicity of the Anthelmintic Emodepside Revealed by Heterologous Expression of Human KCNMA1 in Caenorhabditis elegans

Emodepside is a resistance-breaking anthelmintic of a new chemical class, the cyclooctadepsipeptides. A major determinant of its anthelmintic effect is the calcium-activated potassium channel SLO-1. SLO-1 belongs to a family of channels that are highly conserved across the animal phyla and regulate...

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Bibliografiske detaljer
Main Authors: Crisford, Anna, Murray, Caitriona, O'Connor, Vincent, Edwards, Richard J., Kruger, Nina, Welz, Claudia, von Samson-Himmelstjerna, Georg, Harder, Achim, Walker, Robert J., Holden-Dye, Lindy
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102553/
https://ncbi.nlm.nih.gov/pubmed/21415309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071043
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