Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease

The most common monogenic cause of small-vessel disease leading to ischemic stroke and vascular dementia is the neurodegenerative syndrome cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is associated with mutations in the Notch 3 receptor....

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Autori principali: Arboleda-Velasquez, Joseph F., Manent, Jan, Lee, Jeong Hyun, Tikka, Saara, Ospina, Carolina, Vanderburg, Charles R., Frosch, Matthew P., Rodríguez-Falcón, Manuel, Villen, Judit, Gygi, Steven, Lopera, Francisco, Kalimo, Hannu, Moskowitz, Michael A., Ayata, Cenk, Louvi, Angeliki, Artavanis-Tsakonas, Spyros
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102344/
https://ncbi.nlm.nih.gov/pubmed/21555590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1101964108
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