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Structure of the C-terminal laminin G-like domain pair of the laminin α2 chain harbouring binding sites for α-dystroglycan and heparin

The laminins are large heterotrimeric glycoproteins with fundamental roles in basement membrane architecture and function. The C–terminus of the laminin α chain contains a tandem of five laminin G–like (LG) domains. We report the 2.0 Å crystal structure of the laminin α2 LG4–LG5 domain pair, which h...

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Publicat a:EMBO J
Autors principals: Tisi, Dominic, Talts, Jan F., Timpl, Rupert, Hohenester, Erhard
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2000
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Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310212/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10747011/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.7.1432
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