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The role of reactive oxygen species and autophagy in safingol-induced cell death
Safingol is a sphingolipid with promising anticancer potential, which is currently in phase I clinical trial. Yet, the underlying mechanisms of its action remain largely unknown. We reported here that safingol-induced primarily accidental necrotic cell death in MDA-MB-231 and HT-29 cells, as shown b...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101809/ https://ncbi.nlm.nih.gov/pubmed/21390063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.12 |
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