High-Throughput Screen for Inhibitors of Transglycosylase and/or Transpeptidase Activities of Escherichia coli Penicillin Binding Protein 1b

Penicillin binding protein (PBP) 1b of Escherichia coli has both transglycosylase and transpeptidase activities, which are attractive targets for the discovery of new antibacterial agents. A high-throughput assay that detects inhibitors of the PBPs was described previously, but it cannot distinguish...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Chandrakala, B., Shandil, Radha K., Mehra, Upasana, Ravishankar, Sudha, Kaur, Parvinder, Usha, Veeraraghavan, Joe, Bina, deSousa, Sunita M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2004
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310179/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14693515/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.1.30-40.2004
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