High-Throughput Screen for Inhibitors of Transglycosylase and/or Transpeptidase Activities of Escherichia coli Penicillin Binding Protein 1b

Penicillin binding protein (PBP) 1b of Escherichia coli has both transglycosylase and transpeptidase activities, which are attractive targets for the discovery of new antibacterial agents. A high-throughput assay that detects inhibitors of the PBPs was described previously, but it cannot distinguish...

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Detalhes bibliográficos
Main Authors: Chandrakala, B., Shandil, Radha K., Mehra, Upasana, Ravishankar, Sudha, Kaur, Parvinder, Usha, Veeraraghavan, Joe, Bina, deSousa, Sunita M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC310179/
https://ncbi.nlm.nih.gov/pubmed/14693515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.1.30-40.2004
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