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HIV Replication in CD4+ T Lymphocytes in the Presence and Absence of Follicular Dendritic Cells: Inhibition of Replication mediated by Alpha-1-Antitrypsin through Altered IκBα Ubiquitination

Follicular dendritic cells (FDCs) increase HIV replication and virus production in lymphocytes by increasing the activation of NF-κB in infected cells. Because alpha-1-antitrypsin (AAT) decreases HIV replication in PBMCs and monocytic cells and decreases NF-κB activity, we postulated that AAT might...

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Autors principals: Zhou, Xueyuan, Shapiro, Leland, Fellingham, Gilbert, Willardson, Barry M., Burton, Gregory F.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101708/
https://ncbi.nlm.nih.gov/pubmed/21263074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001358
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