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Decreased Npc1 Gene Dosage in Mice Is Associated With Weight Gain

A recent genome-wide association study has determined that the Niemann-Pick C1 (NPC1) gene is associated with early-onset and morbid adult obesity. However, what effects of the nonsynonymous variation in NPC1 on protein function result in weight gain remains unknown. The NPC1 heterozygous mouse mode...

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Detalhes bibliográficos
Main Authors: Jelinek, David, Heidenreich, Randall A., Erickson, Robert P., Garver, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101636/
https://ncbi.nlm.nih.gov/pubmed/19910939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oby.2009.415
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