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Mechanistic Modeling of the Effects of Glucocorticoids and Circadian Rhythms on Adipokine Expression
A mechanism-based model was developed to describe the effects of methylprednisolone (MPL), circadian rhythms, and the glucose/free fatty acid (FFA)/insulin system on leptin and adiponectin expression in white adipose tissue in rats. Fifty-four normal Wistar rats received 50 mg/kg MPL intramuscularly...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101012/ https://ncbi.nlm.nih.gov/pubmed/21398515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.179960 |
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