The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes

In most mammals, the MHC class I molecules are polymorphic and determine the specificity of peptide presentation, whereas the transporter associated with antigen presentation (TAP) heterodimers are functionally monomorphic. In chickens, there are two classical class I genes but only one is expressed...

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Autores principales: Walker, Brian A., Hunt, Lawrence G., Sowa, Anna K., Skjødt, Karsten, Göbel, Thomas W., Lehner, Paul J., Kaufman, Jim
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100931/
https://ncbi.nlm.nih.gov/pubmed/21536896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019496108
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