GDNF reverses the inhibitory properties of reactive astrocytes allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury

Reactive astrogliosis has been considered as a major impediment for axonal regeneration after injuries in the mammalian central nervous system (CNS). Here we report that glial cell line-derived neurotrophic factor (GDNF), combined with transplanted Schwann cells (SCs), effectively reversed the inhib...

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Hauptverfasser: Deng, Ling-Xiao, Hu, Jianguo, Liu, Naikui, Wang, Xiaofei, Smith, George M., Wen, Xuejun, Xu, Xiao-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100372/
https://ncbi.nlm.nih.gov/pubmed/21316362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.02.001
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