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PTHrP Induces Autocrine/Paracrine Proliferation of Bone Tumor Cells through Inhibition of Apoptosis

Giant Cell Tumor of Bone (GCT) is an aggressive skeletal tumor characterized by local bone destruction, high recurrence rates and metastatic potential. Previous work in our lab has shown that the neoplastic cell of GCT is a proliferating pre-osteoblastic stromal cell in which the transcription facto...

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Detalhes bibliográficos
Main Authors: Mak, Isabella W. Y., Cowan, Robert W., Turcotte, Robert E., Singh, Gurmit, Ghert, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100318/
https://ncbi.nlm.nih.gov/pubmed/21625386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019975
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