Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer

BACKGROUND: Polycomb repressive complex 2 (PRC2) mediates gene silencing through histone H3K27 methylation. PRC2 components are over-expressed in metastatic prostate cancer (PC), and are required for cancer stem cell (CSC) self-renewal. 3-Dezaneplanocin-A (DZNeP) is an inhibitor of PRC2 with broad a...

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Hlavní autoři: Crea, Francesco, Hurt, Elaine M, Mathews, Lesley A, Cabarcas, Stephanie M, Sun, Lei, Marquez, Victor E, Danesi, Romano, Farrar, William L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100246/
https://ncbi.nlm.nih.gov/pubmed/21501485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-40
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