Foxo1 Mediates Insulin-like Growth Factor 1 (IGF1)/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in Osteoblasts

In this study, we determined the molecular mechanisms whereby forkhead transcription factor Foxo1, a key downstream signaling molecule of insulin-like growth factor 1 (IGF1)/insulin actions, regulates Runx2 activity and expression of the mouse osteocalcin gene 2 (Bglap2) in osteoblasts in vitro. We...

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Detalhes bibliográficos
Main Authors: Yang, Shengyong, Xu, Haiyan, Yu, Shibing, Cao, Huiling, Fan, Jie, Ge, Chunxi, Fransceschi, Renny T., Dong, Henry H., Xiao, Guozhi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099728/
https://ncbi.nlm.nih.gov/pubmed/21471200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.197905
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