DNA Binding Restricts the Intrinsic Conformational Flexibility of Methyl CpG Binding Protein 2 (MeCP2)

Mass spectrometry-based hydrogen/deuterium exchange (H/DX) has been used to define the polypeptide backbone dynamics of full-length methyl CpG binding protein 2 (MeCP2) when free in solution and when bound to unmethylated and methylated DNA. Essentially the entire MeCP2 polypeptide chain underwent H...

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Bibliografiska uppgifter
Huvudupphovsmän: Hansen, Jeffrey C., Wexler, Brian B., Rogers, Danielle J., Hite, Kristopher C., Panchenko, Tanya, Ajith, Sandya, Black, Ben E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
DNA and Chromosomes
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099709/
https://ncbi.nlm.nih.gov/pubmed/21467044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.234609
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