Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice

ADAR2, an RNA editing enzyme that converts specific adenosines to inosines in certain pre-mRNAs, often leading to amino acid substitutions in the encoded proteins, is mainly expressed in brain. Of all ADAR2-mediated edits, a single one in the pre-mRNA of the AMPA receptor subunit GluA2 is essential...

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Main Authors: Horsch, Marion, Seeburg, Peter H., Adler, Thure, Aguilar-Pimentel, Juan Antonio, Becker, Lore, Calzada-Wack, Julia, Garrett, Lilian, Götz, Alexander, Hans, Wolfgang, Higuchi, Miyoko, Hölter, Sabine M., Naton, Beatrix, Prehn, Cornelia, Puk, Oliver, Rácz, Ildikó, Rathkolb, Birgit, Rozman, Jan, Schrewe, Anja, Adamski, Jerzy, Busch, Dirk H., Esposito, Irene, Graw, Jochen, Ivandic, Boris, Klingenspor, Martin, Klopstock, Thomas, Mempel, Martin, Ollert, Markus, Schulz, Holger, Wolf, Eckhard, Wurst, Wolfgang, Zimmer, Andreas, Gailus-Durner, Valérie, Fuchs, Helmut, de Angelis, Martin Hrabě, Beckers, Johannes
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099677/
https://ncbi.nlm.nih.gov/pubmed/21467037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.200881
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