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Inhibition of Human Cytochrome P450 3A4 by Cholesterol

Cholesterol has been shown to be hydroxylated at the 4β-position by cytochrome P450 3A4, and the reaction occurs in vivo (Bodin, K., Andersson, U., Rystedt, E., Ellis, E., Norlin, M., Pikuleva, I., Eggertsen, G., Björkhem, I., and Diczfalusy, U. (2002) J. Biol. Chem. 277, 31534–31540). If cholestero...

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Bibliografiske detaljer
Main Authors: Shinkyo, Raku, Guengerich, F. Peter
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099659/
https://ncbi.nlm.nih.gov/pubmed/21471209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240457
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