Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124

The orphan G protein-coupled receptor GPR124/TEM5 is highly expressed in central nervous system (CNS) endothelium. Here, complete null or endothelial-specific GPR124 deletion produced embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube. Conversely, GPR124 overexpre...

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Hlavní autoři: Kuhnert, Frank, Mancuso, Michael R., Shamloo, Amir, Wang, Hsiao-Ting, Choksi, Vir, Florek, Mareike, Su, Hua, Fruttiger, Marcus, Young, William L., Heilshorn, Sarah C., Kuo, Calvin J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099479/
https://ncbi.nlm.nih.gov/pubmed/21071672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1196554
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