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POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders
PURPOSE: To review our clinical experience and determine if there are appropriate signs and symptoms to consider POLG sequencing prior to valproic acid (VPA) dosing in patients with seizures. METHODS: Four patients who developed VPA-induced hepatotoxicity were examined for POLG sequence variations....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3099441/ https://ncbi.nlm.nih.gov/pubmed/20138553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.seizure.2010.01.002 |
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