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RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression
hBRE1/RNF20 is the major E3 ubiquitin ligase for histone H2B. RNF20 depletion causes a global reduction of monoubiquitylated H2B (H2Bub) levels and augments the expression of growth promoting, pro-oncogenic genes. Those genes reside preferentially in compact chromatin, and are inefficiently transcri...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3099049/ https://ncbi.nlm.nih.gov/pubmed/21596312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.03.011 |
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