Chemoprevention of Murine Lung Cancer by Gefitinib in Combination with Prostacyclin Synthase Overexpression

INTRODUCTION: We hypothesized that the combination of the EGFR tyrosine kinase inhibitor (TKI) gefitinib with the powerful chemopreventive manipulation of lung specific transgenic prostacyclin synthase (PGIS) overexpression on tumorigenesis in FVB/N mice would result in augmented chemoprevention. MA...

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Main Authors: Keith, Robert L., Karoor, Vijaya, Mozer, Anthony B., Hudish, Tyler M., Le, Mysan, Miller, York E.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098617/
https://ncbi.nlm.nih.gov/pubmed/20116128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2010.01.004
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