Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of PPARγ

Overexpression of prostacyclin synthase (PGIS) decreases lung tumor multiplicity in chemical and cigarette-smoke induced murine lung cancer models. Prostacyclin signals through a single G-protein coupled receptor (IP), which signals through cAMP. To determine the role of this receptor in lung cancer...

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Main Authors: Nemenoff, Raphael, Meyer, Amy M., Hudish, Tyler M., Mozer, Anthony B., Snee, Amy, Narumiya, Shuh, Stearman, Robert S., Winn, Robert A., Weiser-Evans, Mary, Geraci, Mark W., Keith, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680197/
https://ncbi.nlm.nih.gov/pubmed/19138979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-08-0145
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