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The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets

C-terminal-binding protein (CtBP) is a well-characterized transcriptional co-repressor that requires homo-dimerization for its activity. CtBP can both repress and activate Wingless nuclear targets in Drosophila. Here, we examine the role of CtBP dimerization in these opposing processes. CtBP mutants...

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Detalhes bibliográficos
Main Authors: Bhambhani, Chandan, Chang, Jinhee L, Akey, David L, Cadigan, Ken M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098475/
https://ncbi.nlm.nih.gov/pubmed/21468031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.100
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