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Structure–activity relationships of ustiloxin analogues

Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustilox...

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Hlavní autoři: Joullié, Madeleine M., Berritt, Simon, Hamel, Ernest
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098461/
https://ncbi.nlm.nih.gov/pubmed/21607116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2010.11.165
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