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Top-Down Analysis of Small Plasma Proteins Using an LTQ-Orbitrap. Potential for Mass Spectrometry-Based Clinical Assays for Transthyretin and Hemoglobin

Transthyretin (TTR) amyloidosis and hemoglobinopathies are the archetypes of molecular diseases where point mutation characterization is diagnostically critical. We have developed a Top-down analytical platform for variant and/or modified protein sequencing and are examining the feasibility of using...

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Bibliografske podrobnosti
Main Authors: Théberge, Roger, Infusini, Giuseppe, Tong, Weiwei, McComb, Mark E., Costello, Catherine E.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098445/
https://ncbi.nlm.nih.gov/pubmed/21607198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijms.2010.08.012
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