Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach

BACKGROUND: For heterogeneous tissues, such as blood, measurements of gene expression are confounded by relative proportions of cell types involved. Conclusions have to rely on estimation of gene expression signals for homogeneous cell populations, e.g. by applying micro-dissection, fluorescence act...

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Main Authors: Repsilber, Dirk, Kern, Sabine, Telaar, Anna, Walzl, Gerhard, Black, Gillian F, Selbig, Joachim, Parida, Shreemanta K, Kaufmann, Stefan HE, Jacobsen, Marc
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098067/
https://ncbi.nlm.nih.gov/pubmed/20070912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-11-27
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