The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer

BACKGROUND: Dietary or therapeutic interventions to counteract the loss of PTEN expression could contribute to the prevention of prostate carcinogenesis or reduce the rate of cancer progression. In this study, we investigate the interaction between sulforaphane, a dietary isothiocyanate derived from...

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Detalhes bibliográficos
Main Authors: Traka, Maria H, Spinks, Caroline A, Doleman, Joanne F, Melchini, Antonietta, Ball, Richard Y, Mills, Robert D, Mithen, Richard F
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098008/
https://ncbi.nlm.nih.gov/pubmed/20626841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-189
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